Вот идут неандертальцы
Jan. 30th, 2019 08:50 pm![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
behma_coderrr
склонные к депрессии
от Алтая до Хорватии
https://www.ncbi.nlm.nih.gov/pubmed/28982794
приспособленные холодам и умеренности в потомстве
https://www.nature.com/articles/nature12961
https://www.the-scientist.com/news-opinion/neanderthal-ancestry-in-europeans-unchanged-for-last-45-000-years-65364
no subject
Date: 2019-02-01 07:19 am (UTC)no subject
Date: 2019-02-01 03:54 pm (UTC)Evidence that Neanderthal communities were much smaller than human ones have led researchers to believe that weakly harmful variants—which would have been quickly removed from bigger groups with more genetic diversity—accumulated in Neanderthal genomes. “When populations are smaller, [natural] selection isn’t as strong,” explains Benjamin Vernot, a population geneticist at the Max Planck Institute for Evolutionary Anthropology and one of the coauthors of the latest study. “So on average, Neanderthals would have had more bad mutations in their genome than modern human individuals.”
исследователи никак не могли связать вырождение генома метисов с естественным отбором.
Vernot and his colleagues set out to identify whether a different model of natural selection could explain the gradual decrease of Neanderthal DNA in ancient Eurasian genomes. “We tried a bunch of things and none of them worked,” Vernot says. “We drove ourselves nuts trying to figure out how to make this decline over time, because that’s what we saw in the data.”
https://www.the-scientist.com/news-opinion/neanderthal-ancestry-in-europeans-unchanged-for-last-45-000-years-65364
интересно Астеррот связывает элиты с доиндоевропейским заселением Европы. Как это? Люди буквально за поколение опыт и понимание утрачивают. Проверено.
Вернемся к нашим бара.. предкам.
Здесь под сомнение ставят естественный отбор. Одинаково отсеивал цепочки.
Under this model, deleterious haplotypes introgressed into larger modern human populations would have been subject to strong selection during the first ∼20 generations after hybridization—a prediction with growing empirical support from genetic data (Sankararaman et al., 2014
, Sankararaman et al., 2016
, Vernot et al., 2016
, Currat and Excoffier, 2011
). Nevertheless, many weakly deleterious variants (s < 5 × 10−4) are predicted to persist in present-day human populations, with a cumulative impact comparable to that of the Out-of-Africa bottleneck (Harris and Nielsen, 2016
). As many of these deleterious mutations presumably influence gene regulation, we hypothesized that Neanderthal-introgressed variants may be enriched for ASE compared to segregating mutations that arose in modern humans. We therefore contrasted the proportions of introgressed and non-introgressed variants exhibiting significant ASE, stratifying by derived allele frequency to control for power differences (see STAR Methods). Within frequency bins, we found no significant differences between the proportions of introgressed and non-introgressed SNPs exhibiting ASE (Figure 4B). This finding suggests that purifying selection after introgression has largely equalized the frequencies of introgressed and non-introgressed regulatory variants with similar magnitudes of allelic effects.
То есть наиболее вредные аллели неандров отсеивались в течении 20 поколений, также как и с любой замкнутой популяцией гомо африканцев.
https://www.cell.com/cell/fulltext/S0092-8674(17)30128-9
Ну а то что люди с розовыми щечками долго держали чистых кроманьонцев в цепях как бы намекает.
Здесь я с Ужасом соглашусь, что выбор профессии и местные условия больше влияет на битие, чем наследственность.
Чечены вряд ли думают, что они этруски. И отсюда их сила.
Объяснение этрусскости московского хе-хе чеченца астеррота
посему не принимаю.
Еще раз. В прикладном аспекте. Фуражка на голове отца, деда, а уже, что актуально, и прадеда, больше роляет, чем генетический отсев двадцати поколений.